Wednesday, 29 February 2012

finasteride



Generic Name: finasteride (fih NAH steh ride)

Brand Names: Propecia, Proscar


What is finasteride?

Finasteride prevents the conversion of testosterone to dihydrotestosterone (DHT) in the body. DHT is involved in the development of benign prostatic hyperplasia (BPH).


Finasteride (Propecia) is used for the treatment of male pattern hair loss. Finasteride (Proscar) is used to treat symptoms of benign prostatic hyperplasia (BPH) in men with an enlarged prostate.


Finasteride may also be used for purposes not listed in this medication guide.


What is the most important information I should know about finasteride?


Finasteride should never be taken by a woman or a child. Finasteride can be absorbed through the skin, and women or children should not be permitted to handle finasteride tablets. Although finasteride is not for use by women, this medication can cause birth defects if a woman is exposed to it during pregnancy. Finasteride tablets should not be handled by a woman who is pregnant or who may become pregnant. If a woman accidentally comes into contact with this medication from a broken or crushed tablet, wash the area with soap and water right away. Before taking finasteride, tell your doctor if you have ever had an allergic reaction to this medication, or to a similar medicine called dutasteride (Avodart).

Using finasteride may increase your risk of developing prostate cancer. Your doctor will perform tests to make sure you do not have other conditions that would prevent you from safely using finasteride.


Call your doctor at once if you notice any breast lumps, pain, nipple discharge, or other breast changes. These may be signs of male breast cancer.

What should I discuss with my healthcare provider before taking finasteride?


Finasteride should never be taken by a woman or a child. Finasteride can be absorbed through the skin, and women or children should not be permitted to handle finasteride tablets.

To make sure you can safely take finasteride, tell your doctor if you have any of these other conditions:



  • liver disease, or abnormal liver enzyme tests;




  • prostate cancer;




  • a bladder muscle disorder;




  • stricture of your urethra;




  • if you are unable to urinate; or




  • if you have ever had an allergic reaction to a similar medicine called dutasteride (Avodart).




Using finasteride may increase your risk of developing prostate cancer. Your doctor will perform tests to make sure you do not have other conditions that would prevent you from safely using finasteride. Although finasteride is not for use by women, this medication can cause birth defects if a woman is exposed to it during pregnancy. Finasteride tablets should not be handled by a woman who is pregnant or who may become pregnant. If a woman accidentally comes into contact with this medication from a broken or crushed tablet, wash the area with soap and water right away.

How should I take finasteride?


Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.


Take this medicine with a full glass of water.

Finasteride can be taken with or without food. Take the medicine at the same time each day.


To be sure this medication is helping your condition and not causing harmful effects, your blood may need to be tested often. Your doctor will also test your prostate specific antigen (PSA) to check for prostate cancer. Visit your doctor regularly.

Use finasteride regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.


Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.

See also: Finasteride dosage (in more detail)

What happens if I miss a dose?


Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.


What happens if I overdose?


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking finasteride?


Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.


Finasteride side effects


Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you notice any breast lumps, pain, nipple discharge, or other breast changes. These may be signs of male breast cancer.

Less serious side effects may include:



  • impotence, loss of interest in sex, or trouble having an orgasm;




  • abnormal ejaculation;




  • swelling in your hands or feet;




  • swelling or tenderness in your breasts;




  • dizziness, weakness;




  • feeling like you might pass out;




  • headache;




  • runny nose; or




  • skin rash.



This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Finasteride Dosing Information


Usual Adult Dose for Benign Prostatic Hyperplasia:

5 mg orally once a day.

Patients should be evaluated for efficacy after 6 to 12 months. If after this time there is no improvement, finasteride should be discontinued. Doses greater than 5 mg/day do not result in increased dihydrotestosterone suppression and should not be used.

Several long-term studies (up to ten years) have concluded that finasteride leads to durable improvement in urinary tract symptoms, flow rate, and prostate volume.

Usual Adult Dose for Androgenetic Alopecia:

For the treatment of male pattern hair loss (androgenetic alopecia) in men only . (Safety and efficacy have been demonstrated in men between 18 to 41 years of age with mild to moderate hair loss of the vertex and anterior mid scalp area.):

Recommended Dosage: 1 mg once a day.

In general, daily use for three months or more is necessary before benefit is observed. Continued use is recommended to sustain benefit. Withdrawal of treatment leads to reversal of effect within 12 months.


What other drugs will affect finasteride?


There may be other drugs that can interact with finasteride. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.



More finasteride resources


  • Finasteride Side Effects (in more detail)
  • Finasteride Dosage
  • Finasteride Use in Pregnancy & Breastfeeding
  • Drug Images
  • Finasteride Drug Interactions
  • Finasteride Support Group
  • 11 Reviews for Finasteride - Add your own review/rating


  • finasteride Advanced Consumer (Micromedex) - Includes Dosage Information

  • Finasteride Prescribing Information (FDA)

  • Finasteride Professional Patient Advice (Wolters Kluwer)

  • Finasteride Monograph (AHFS DI)

  • Finasteride MedFacts Consumer Leaflet (Wolters Kluwer)

  • Propecia Prescribing Information (FDA)

  • Propecia MedFacts Consumer Leaflet (Wolters Kluwer)

  • Propecia Consumer Overview

  • Proscar Prescribing Information (FDA)

  • Proscar Consumer Overview



Compare finasteride with other medications


  • Androgenetic Alopecia
  • Benign Prostatic Hyperplasia


Where can I get more information?


  • Your pharmacist can provide more information about finasteride.

See also: finasteride side effects (in more detail)


Tuesday, 28 February 2012

Niacinamide


Pronunciation: NYE-a-sin-a-mide
Generic Name: Niacinamide
Brand Name: Generic only. No brands available.


Niacinamide is used for:

Treating or preventing low levels of niacin (vitamin B3). It may also be used for other conditions as determined by your doctor.


Niacinamide is a vitamin B supplement. It works by replacing vitamin B3 in the body.


Do NOT use Niacinamide if:


  • you are allergic to any ingredient in Niacinamide

Contact your doctor or health care provider right away if any of these apply to you.



Before using Niacinamide:


Some medical conditions may interact with Niacinamide. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:


  • if you are pregnant, planning to become pregnant, or are breast-feeding

  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

  • if you have allergies to medicines, foods, or other substances

  • if you have diabetes, liver disease, an ulcer, glaucoma, or low blood pressure

  • if you have severe bleeding

Some MEDICINES MAY INTERACT with Niacinamide. Tell your health care provider if you are taking any other medicines, especially any of the following:


  • Fibrates (eg, gemfibrozil, fenofibrate) or HMG-CoA reductase inhibitors (statins) (eg, simvastatin) because side effects, such as muscle aches and weakness, may occur and may be a symptom of a serious medical condition called rhabdomyolysis

  • Alcohol because toxic effects, such as delirium and lactic acidosis, may occur

This may not be a complete list of all interactions that may occur. Ask your health care provider if Niacinamide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.


How to use Niacinamide:


Use Niacinamide as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • Take Niacinamide by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.

  • If you miss taking a dose of Niacinamide for 1 or more days, there is no cause for concern. If your doctor recommended that you take it, try to remember your dose every day.

Ask your health care provider any questions you may have about how to use Niacinamide.



Important safety information:


  • Niacinamide may cause dizziness, lightheadedness, or fainting. These effects may be worse if you take it with alcohol or certain medicines. Use Niacinamide with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

  • Do not take large doses of vitamins while you use Niacinamide unless your doctor tells you to.

  • Diabetes patients - Niacinamide may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Niacinamide while you are pregnant. Niacinamide is found in breast milk. If you are or will be breast-feeding while you use Niacinamide, check with your doctor. Discuss any possible risks to your baby.


Possible side effects of Niacinamide:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:



Diarrhea; dizziness; headache; itching; nausea; stomach upset; temporary feeling of warmth or flushing of the skin.



Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry, or bloody stools; changes in vision; dark urine; decreased urination; fast or irregular heartbeat; loss of appetite; muscle pain or weakness; numbness or persistent tingling of the skin; persistent nausea, vomiting, or general "unwell" feeling; severe or prolonged flushing of the skin; stomach pain; swelling of the hands, legs, or feet; vomit that looks like coffee grounds; yellowing of the skin or eyes.



This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.


See also: Niacinamide side effects (in more detail)


If OVERDOSE is suspected:


Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.


Proper storage of Niacinamide:

Store Niacinamide at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Niacinamide out of the reach of children and away from pets.


General information:


  • If you have any questions about Niacinamide, please talk with your doctor, pharmacist, or other health care provider.

  • Niacinamide is to be used only by the patient for whom it is prescribed. Do not share it with other people.

  • If your symptoms do not improve or if they become worse, check with your doctor.

  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Niacinamide. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.



Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Niacinamide resources


  • Niacinamide Side Effects (in more detail)
  • Niacinamide Use in Pregnancy & Breastfeeding
  • Niacinamide Drug Interactions
  • Niacinamide Support Group
  • 0 Reviews for Niacinamide - Add your own review/rating


Compare Niacinamide with other medications


  • Niacin Deficiency
  • Pemphigus